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Pteryxin

CAT: 0804-HY-N2157-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2157-01Size:1 mg
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Description
Pteryxin ((+) -Pteryxin) is an orally active multi-target inhibitor that targets NF-κB, MAPK, NLRP3 inflammasome, and Nrf2/ARE pathways. Pteryxin is also a BChE inhibitor (IC50=12.96 μg/mL) with a low inhibitory efficiency on AChE. Pteryxin inhibits the Ca2+-calcineurin-NFATc1 pathway by blocking NF-κB/MAPK signaling, inhibiting NLRP3 inflammasome activation, and reducing ROS generation, and activates Nrf2-mediated antioxidant enzyme expression. Pteryxin has anti-inflammatory, antioxidant, and osteoclastogenesis inhibitory activities. Pteryxin can be used in the study of inflammatory diseases, osteoporosis, diabetes, and Alzheimer's disease[1][2][3][4][5].
CAS Number
13161-75-6
Product Name Alternative
(+) -Pteryxin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cholinesterase (ChE) ; Keap1-Nrf2; NF-κB; NOD-like Receptor (NLR) ; Nuclear Factor of activated T Cells (NFAT) ; p38 MAPK; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pteryxin.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C/C=C(C)\C(O[C@@H]1C2=C3C(C=CC(O3)=O)=CC=C2OC(C)(C)[C@@H]1OC(C)=O)=O
Molecular Formula
C21H22O7
Molecular Weight
386.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhen D, et al. Pteryxin attenuates LPS-induced inflammatory responses and inhibits NLRP3 inflammasome activation in RAW264.7 cells. J Ethnopharmacol. 2022 Feb 10;284:114753.|[2]Sun R, et al. Pteryxin suppresses osteoclastogenesis and prevents bone loss via inhibiting the MAPK/Ca2+ signaling pathways mediated by ROS. Biomed Pharmacother. 2023 Sep;165:114898.|[3]Taira J, et al. Cytoprotective Effect of Pteryxin on Insulinoma MIN6 Cells Due to Antioxidant Enzymes Expression via Nrf2/ARE Activation. Antioxidants (Basel) . 2023 Mar 10;12 (3) :693.|[4]Kiris I, et al. Molecular Effects of Pteryxin and Scopoletin in the 5xFAD Alzheimer's Disease Mouse Model. Curr Med Chem. 2022;29 (16) :2937-2950.|[5]Orhan IE, et al. Pteryxin - A promising butyrylcholinesterase-inhibiting coumarin derivative from Mutellina purpurea. Food Chem Toxicol. 2017 Nov;109 (Pt 2) :970-974.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE; BChE; NLRP3

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