Pterosin B

• Description:

  Pterosin B is an orally active indanone. Pterosin B can be obtained from Pteridium aquilinum. Pterosin B is a Sik3 signaling inhibitor. Pterosin B inhibits Klf5 expression and reduces β-amyloid deposition. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice. Pterosin B inhibits cardiomyocyte hypertrophy, improves cognitive impairment, and lowers blood glucose. Pterosin B can be used in research on arthritis, Alzheimer's disease, pathological cardiac hypertrophy and diabetes[1][2][3][4][5].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Amyloid-β; KLF; Salt-inducible Kinase (SIK)

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Endocrinology; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/pterosin-b.html

• Purity:

  99.98

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C1[C@H] (C) CC2=C1C (C) =C (CCO) C (C) =C2

• Molecular Formula:

  C14H18O2

• Molecular Weight:

  218.30

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Hannah R.Dexter, et al. A concise stereoselective synthesis of pterosin B. Tetrahedron Letters, Volume 59, Issue 49, 5 December 2018, Pages 4323-4325.|[2]Yahara Y, et al. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat Commun. 2016 Mar 24;7:10959.|[3]Lee C Y, et al. Novel therapeutic effects of pterosin B on Ang II-induced cardiomyocyte hypertrophy. Molecules, 2020, 25 (22) : 5279.|[4]Zhang Y, et al. Pterosin B improves cognitive dysfunction by promoting microglia M1/M2 polarization through inhibiting Klf5/Parp14 pathway. Phytomedicine. 2024 Dec;135:156152.|[5]Itoh Y. Pterosin B, ingredient in Pteridium aquilinum, regulates hepatic gluconeogenesis via SIK3-dependent and independent mechanisms. 2017.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  SIK3

• CAS Number:

  34175-96-7