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Pterosin B (Standard)

CAT: 0804-HY-N1570RSize: 1 EachDry Ice: NoHazardous: No
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Description
Pterosin B (Standard) is the analytical standard of Pterosin B. This product is intended for research and analytical applications. Pterosin B is an indanone. Pterosin B can be obtained from Pteridium aquilinum. Pterosin B is a Sik3 signaling inhibitor. Pterosin B inhibits Klf5 expression and reduces β-amyloid deposition. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice. Pterosin B inhibits cardiomyocyte hypertrophy, improves cognitive impairment, and lowers blood glucose. Pterosin B can be used in research on arthritis, Alzheimer's disease, pathological cardiac hypertrophy and diabetes[1][2][3][4][5].
CAS Number
34175-96-7
UNSPSC
12352005
Target
Amyloid-β; KLF; Reference Standards; Salt-inducible Kinase (SIK)
Type
Reference Standards
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Others
Field of Research
Endocrinology; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pterosin-b-standard.html
Smiles
O=C1[C@H](C)CC2=C1C(C)=C(CCO)C(C)=C2
Molecular Formula
C14H18O2
Molecular Weight
218.29
References & Citations
[1]Hannah R.Dexter, et al. A concise stereoselective synthesis of pterosin B. Tetrahedron Letters, Volume 59, Issue 49, 5 December 2018, Pages 4323-4325.|[2]Yahara Y, et al. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat Commun. 2016 Mar 24;7:10959.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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