Pterosin B (Standard)

• Description :

  Pterosin B (Standard) is the analytical standard of Pterosin B (HY-N1570) . This product is intended for research and analytical applications. Pterosin B is an indanone. Pterosin B can be obtained from Pteridium aquilinum. Pterosin B is a Sik3 signaling inhibitor. Pterosin B inhibits Klf5 expression and reduces β-amyloid deposition. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice. Pterosin B inhibits cardiomyocyte hypertrophy, improves cognitive impairment, and lowers blood glucose. Pterosin B can be used in research on arthritis, Alzheimer's disease, pathological cardiac hypertrophy and diabetes[1][2][3][4][5].

• UNSPSC :

  12352005

• Target :

  Amyloid-β; KLF; Reference Standards; Salt-inducible Kinase (SIK)

• Type :

  Reference Standards

• Related Pathways :

  Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Others

• Field of Research :

  Endocrinology; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/pterosin-b-standard.html

• Smiles :

  O=C1[C@H](C)CC2=C1C(C)=C(CCO)C(C)=C2

• Molecular Formula :

  C14H18O2

• Molecular Weight :

  218.29

• References & Citations :

  [1]Hannah R.Dexter, et al. A concise stereoselective synthesis of pterosin B. Tetrahedron Letters, Volume 59, Issue 49, 5 December 2018, Pages 4323-4325.|[2]Yahara Y, et al. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat Commun. 2016 Mar 24;7:10959.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [34175-96-7]