Pterosin A

• Description :

  Pterosin A ((2S) -Pterosin A) is a sesquiterpene compound. Pterosin A is an orally active AMPK activator with anti-diabetic effect. Pterosin A can promote glucose uptake, increase serum insulin, and improve hyperglycemia and glucose intolerance. Pterosin A can prevent insulin-secreting cells death and reduce ROS production. Pterosin A can be used for the research of metabolic disease, such as diabetes[1][2].

• Product Name Alternative :

  (2S) -Pterosin A

• UNSPSC :

  12352005

• Target :

  Akt; AMPK; GLUT; GSK-3; p38 MAPK; PEPCK; Reactive Oxygen Species (ROS)

• Type :

  Natural Products

• Related Pathways :

  Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/pterosin-a.html

• Purity :

  94.07

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1C(C(C[C@](C)1CO)=CC(C)=C2CCO)=C2C

• Molecular Formula :

  C15H20O3

• Molecular Weight :

  248.32

• References & Citations :

  [1]Hsu FL, et al. Antidiabetic effects of pterosin A, a small-molecular-weight natural product, on diabetic mouse models. Diabetes. 2013 Feb;62 (2) :628-38.|[2]Chen CY, et al. Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan. Int J Mol Sci. 2015 Jan 22;16 (2) :2497-516.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  GLUT4

• CAS Number :

  [35910-16-8]