Pterosin A

CAT: 0804-HY-N7912Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N7912Size:1 mg
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Description
Pterosin A ((2S) -Pterosin A) is a sesquiterpene compound. Pterosin A is an orally active AMPK activator with anti-diabetic effect. Pterosin A can promote glucose uptake, increase serum insulin, and improve hyperglycemia and glucose intolerance. Pterosin A can prevent insulin-secreting cells death and reduce ROS production. Pterosin A can be used for the research of metabolic disease, such as diabetes[1][2].
CAS Number
[35910-16-8]
Product Name Alternative
(2S) -Pterosin A
UNSPSC
12352005
Target
Akt; AMPK; GLUT; GSK-3; p38 MAPK; PEPCK; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pterosin-a.html
Purity
94.07
Solubility
10 mM in DMSO
Smiles
O=C1C(C(C[C@](C)1CO)=CC(C)=C2CCO)=C2C
Molecular Formula
C15H20O3
Molecular Weight
248.32
References & Citations
[1]Hsu FL, et al. Antidiabetic effects of pterosin A, a small-molecular-weight natural product, on diabetic mouse models. Diabetes. 2013 Feb;62 (2) :628-38.|[2]Chen CY, et al. Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan. Int J Mol Sci. 2015 Jan 22;16 (2) :2497-516.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
GLUT4

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