Pterosin A

• Description:

  Pterosin A ((2S) -Pterosin A) is a sesquiterpene compound. Pterosin A is an orally active AMPK activator with anti-diabetic effect. Pterosin A can promote glucose uptake, increase serum insulin, and improve hyperglycemia and glucose intolerance. Pterosin A can prevent insulin-secreting cells death and reduce ROS production. Pterosin A can be used for the research of metabolic disease, such as diabetes[1][2].

• Product Name Alternative:

  (2S) -Pterosin A

• UNSPSC:

  12352005

• Target:

  Akt; AMPK; GLUT; GSK-3; p38 MAPK; PEPCK; Reactive Oxygen Species (ROS)

• Type:

  Natural Products

• Related Pathways:

  Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/pterosin-a.html

• Purity:

  94.07

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C(C(C[C@](C)1CO)=CC(C)=C2CCO)=C2C

• Molecular Formula:

  C15H20O3

• Molecular Weight:

  248.32

• References & Citations:

  [1]Hsu FL, et al. Antidiabetic effects of pterosin A, a small-molecular-weight natural product, on diabetic mouse models. Diabetes. 2013 Feb;62 (2) :628-38.|[2]Chen CY, et al. Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan. Int J Mol Sci. 2015 Jan 22;16 (2) :2497-516.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  GLUT4

• CAS Number:

  [35910-16-8]