(-) - (E) -Guggulsterone (Standard)

CAT: 0804-HY-N7781R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N7781R-01Size:5 mg
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Description
(-) - (E) -guggulsterone (Standard) is the analytical standard for (-) - (E) -guggulsterone ((E) -Guggulsterone) (HY-N7781) . (-) - (E) -Guggulsterone is an orally active natural stereoisomer of Guggulsterone (HY-107738) . (-) - (E) -Guggulsterone is an antagonist for the Farnesoid X Receptor (FXR) with an IC50 of 24.06 μM and possesses potent hypolipidemic properties. (-) - (E) -Guggulsterone suppresses dengue virus (DENV) replication by upregulating antiviral interferon responses by inducing HO-1 expression via Nrf2 activation. (-) - (E) -Guggulsterone exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa. (-) - (E) -Guggulsterone has cardiac protective and antioxidant activities in rats.
CAS Number
[39025-24-6]
Product Name Alternative
(E) -Guggulsterone (Standard)
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Bacterial; Cytochrome P450; Dengue Virus; Drug Metabolite; Estrogen Receptor/ERR; FXR; Heme Oxygenase (HO) ; Keap1-Nrf2; Reactive Oxygen Species (ROS) ; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Infection; Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/minus-e-guggulsterone-standard.html
Smiles
C/C=C1C(C[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]/12C)=O)=O
Molecular Formula
C21H28O2
Molecular Weight
312.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
No Development Reported

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