(-) - (E) -Guggulsterone (Standard)

• Description:

  (-) - (E) -guggulsterone (Standard) is the analytical standard for (-) - (E) -guggulsterone ((E) -Guggulsterone) (HY-N7781) . (-) - (E) -Guggulsterone is an orally active natural stereoisomer of Guggulsterone (HY-107738) . (-) - (E) -Guggulsterone is an antagonist for the Farnesoid X Receptor (FXR) with an IC50 of 24.06 μM and possesses potent hypolipidemic properties. (-) - (E) -Guggulsterone suppresses dengue virus (DENV) replication by upregulating antiviral interferon responses by inducing HO-1 expression via Nrf2 activation. (-) - (E) -Guggulsterone exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa. (-) - (E) -Guggulsterone has cardiac protective and antioxidant activities in rats.

• Product Name Alternative:

  (E) -Guggulsterone (Standard)

• UNSPSC:

  12352211

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Bacterial; Cytochrome P450; Dengue Virus; Drug Metabolite; Estrogen Receptor/ERR; FXR; Heme Oxygenase (HO) ; Keap1-Nrf2; Reactive Oxygen Species (ROS) ; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Infection; Endocrinology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/minus-e-guggulsterone-standard.html

• Smiles:

  C/C=C1C(C[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]/12C)=O)=O

• Molecular Formula:

  C21H28O2

• Molecular Weight:

  312.45

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• Clinical Information:

  No Development Reported

• CAS Number:

  [39025-24-6]