(Z) -Guggulsterone

• Description:

  (Z) -Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z) -Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1]. (Z) -Guggulsterone is also a potent FXR antagonist. (Z) -Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection[2].

• UNSPSC:

  12352211

• Hazard Statement:

  H335

• Target:

  Akt; Angiotensin-converting Enzyme (ACE) ; Apoptosis; FXR; SARS-CoV; VEGFR

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/z-guggulsterone.html

• Purity:

  99.41

• Solubility:

  DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  C[C@@]1(/C2=C/C)[C@](CC2=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1.[Z]

• Molecular Formula:

  C21H28O2

• Molecular Weight:

  312.45

• Precautions:

  H335

• References & Citations:

  [1]Xiao D, et al. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther. 2008 Jan;7 (1) :171-80.|[2]Brevini T, et al. FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. Nature. 2022 Dec 5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  VEGFR2/KDR/Flk-1

• CAS Number:

  [39025-23-5]