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(Z) -Guggulsterone

CAT: 0804-HY-110066-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110066-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(Z) -Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z) -Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1]. (Z) -Guggulsterone is also a potent FXR antagonist. (Z) -Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection[2].
CAS Number
39025-23-5
UNSPSC
12352211
Hazard Statement
H335
Target
Akt; Angiotensin-converting Enzyme (ACE) ; Apoptosis; FXR; SARS-CoV; VEGFR
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/z-guggulsterone.html
Purity
99.41
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@@]1(/C2=C/C)[C@](CC2=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1.[Z]
Molecular Formula
C21H28O2
Molecular Weight
312.45
Precautions
H335
References & Citations
[1]Xiao D, et al. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther. 2008 Jan;7 (1) :171-80.|[2]Brevini T, et al. FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. Nature. 2022 Dec 5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1

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