(E, E) -Bisdemethoxycurcumin (Standard)

• Description:

  (E, E) -Bisdemethoxycurcumin (Standard) is the analytical standard of (E, E) -Bisdemethoxycurcumin. This product is intended for research and analytical applications. (E, E) -Bisdemethoxycurcumin ((E, E) -Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities[1][2][3][4][5][6].

• Product Name Alternative:

  (E, E) -Curcumin III (Standard) ; (E, E) -Didemethoxycurcumin (Standard)

• UNSPSC:

  12352005

• Target:

  Apoptosis; Autophagy; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Apoptosis; Autophagy; Others

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/e-e-bisdemethoxycurcumin-standard.html

• Smiles:

  O=C (CC (/C=C/C1=CC=C (O) C=C1) =O) /C=C/C2=CC=C (O) C=C2

• Molecular Formula:

  C19H16O4

• Molecular Weight:

  308.33

• References & Citations:

  [1]Lee PJ, et al. Bisdemethoxycurcumin Induces Apoptosis in Activated Hepatic Stellate Cells via Cannabinoid Receptor 2. Molecules. 2015 Jan 14;20 (1) :1277-92.|[2]Chen J, et al. Natural borneol enhances bisdemethoxycurcumin-induced cell cycle arrest in the G2/M phase through up-regulation of intracellular ROS in HepG2 cells. Food Funct. 2014 Dec 24.|[3]Luo C, et al. Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction. Oncol Lett. 2015 Jan;9 (1) :270-274.|[4]Li YB, et al. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med. 2013;2013:851714.|[5]Yodkeeree S, et al. Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA. J Nutr Biochem. 2009 Feb;20 (2) :87-95.|[6]Lai CS, et al. Bisdemethoxycurcumin Inhibits Adipogenesis in 3T3-L1 Preadipocytes and Suppresses Obesity in High-Fat Diet-Fed C57BL/6 Mice. J Agric Food Chem. 2016 Feb 3;64 (4) :821-30.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  33171-05-0