Guggulsterone

• Description :

  Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt[1][2]. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-) - (E) -Guggulsterone (HY-N7781) and (Z) -Guggulsterone (HY-110066), respectively[3].

• Product Name Alternative :

  Z/E-Guggulsterone

• UNSPSC :

  12352211

• Hazard Statement :

  H315, H319, H335

• Target :

  Akt; Apoptosis; Autophagy; Caspase; FXR; JNK

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Autophagy; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/guggulsterone.html

• Concentration :

  10mM

• Purity :

  99.83

• Solubility :

  DMSO : 20.83 mg/mL (ultrasonic)

• Smiles :

  C[C@@]1(/C2=C/C)[C@](CC2=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1

• Molecular Formula :

  C21H28O2

• Molecular Weight :

  312.45

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Shishodia S, et al. Guggulsterone for Chemoprevention of Cancer. Curr Pharm Des. 2016;22 (3) :294-306.|[2]Che X, et al. Protective effects of guggulsterone against colitis are associated with the suppression of TREM-1 and modulation of macrophages. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315 (1) :G128-G139.|[3]Hsu CW, et al. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Caspase; JNK

• CAS Number :

  [95975-55-6]