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Guggulsterone

CAT: 0804-HY-107738-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107738-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt[1][2]. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-) - (E) -Guggulsterone and (Z) -Guggulsterone (HY-110066), respectively[3].
CAS Number
95975-55-6
Product Name Alternative
Z/E-Guggulsterone
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Akt; Apoptosis; Autophagy; Caspase; FXR; JNK
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/guggulsterone.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 20.83 mg/mL (ultrasonic)
Smiles
C[C@@]1(/C2=C/C)[C@](CC2=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1
Molecular Formula
C21H28O2
Molecular Weight
312.45
Precautions
H315, H319, H335
References & Citations
[1]Shishodia S, et al. Guggulsterone for Chemoprevention of Cancer. Curr Pharm Des. 2016;22 (3) :294-306.|[2]Che X, et al. Protective effects of guggulsterone against colitis are associated with the suppression of TREM-1 and modulation of macrophages. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315 (1) :G128-G139.|[3]Hsu CW, et al. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase; JNK

Alternative Products

CatalogName
540188Guggulsterone
B7431-50Z-Guggulsterone
FG39357-01(E) -Guggulsterone
MBS3613980-01(Z)-Guggulsterone
A19825-100Guggulsterone 100mg
A19825-5Guggulsterone 5mg
abx283175-01Guggulsterone (Z-)
A19825-1Guggulsterone 1mg
TRC-G852005-50MG(E)-Guggulsterone

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