SW-100

• UNSPSC Description:

  SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier[1].

• Target Antigen:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/sw-100.html

• Purity:

  99.93

• Solubility:

  DMSO : ≥ 125 mg/mL

• Smiles:

  O=C(NO)C1=CC=C(CN2CCCC3=C2C=CC(Cl)=C3)C=C1

• Molecular Weight:

  316.78

• References & Citations:

  [1]Kozikowski AP, et al. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10(3):1679-1695.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2126744-35-0