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SW-100

CAT: 0804-HY-115475-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115475-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier[1].
CAS Number
2126744-35-0
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sw-100.html
Purity
99.93
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C(NO)C1=CC=C(CN2CCCC3=C2C=CC(Cl)=C3)C=C1
Molecular Formula
C17H17ClN2O2
Molecular Weight
316.78
References & Citations
[1]Kozikowski AP, et al. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1679-1695.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9

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Alternative Products

CatalogName
BA4129-1SW-100
A18947-100SW-100 100mg
A18947-10SW-100 10mg
A18947-5SW-100 5mg
A18947-1SW-100 1mg
A18947-25SW-100 25mg
A18947-50SW-100 50mg
A18947-10mM-DSW-100 10mM * 1mL in DMSO

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