SW-106

CAT: 0804-HY-113918Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-113918Size:1 Each
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Description
SW-106 is a parathyroid hormone receptor 1 (PTHR1) antagonist. SW106 antagonizes PTHR1-mediated cAMP signaling induced by the peptide analog, M-PTH (1-11), as well as by the native PTH (1-9) sequence, as tethered to the extracellular end of transmembrane domain (TMD) helix-1 of the receptor. SW-106 can be used for the research of metabolic disease[1].
CAS Number
[1027921-53-4]
UNSPSC
12352005
Target
PTHR
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease
Smiles
O=C1NC2=CC=C(F)C(F)=C2[C@](C(F)(F)F)(/C=C/C3CC3)O[C@H]1CC
Molecular Formula
C17H16F5NO2
Molecular Weight
361.31
References & Citations
[1]Carter PH, Dean T, Bhayana B, Khatri A, Rajur R, Gardella TJ. Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor. Mol Endocrinol. 2015 Feb;29 (2) :307-21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PTH1R

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