SW-106

• Description:

  SW-106 is a parathyroid hormone receptor 1 (PTHR1) antagonist. SW106 antagonizes PTHR1-mediated cAMP signaling induced by the peptide analog, M-PTH (1-11), as well as by the native PTH (1-9) sequence, as tethered to the extracellular end of transmembrane domain (TMD) helix-1 of the receptor. SW-106 can be used for the research of metabolic disease[1].

• UNSPSC:

  12352005

• Target:

  PTHR

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Metabolic Disease

• Smiles:

  O=C1NC2=CC=C(F)C(F)=C2[C@](C(F)(F)F)(/C=C/C3CC3)O[C@H]1CC

• Molecular Formula:

  C17H16F5NO2

• Molecular Weight:

  361.31

• References & Citations:

  [1]Carter PH, Dean T, Bhayana B, Khatri A, Rajur R, Gardella TJ. Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor. Mol Endocrinol. 2015 Feb;29 (2) :307-21.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PTH1R

• CAS Number:

  [1027921-53-4]