COMT-IN-1

CAT: 0804-HY-162760Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-162760Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

COMT-IN-1 (compound C12), a nitrophenolic analogue, is an orally active dopamine metabolic enzyme catechol-O-methyltransferase (COMT) inhibitor with IC50s of 0.37 μM, 95.58 μM and 58.82 μM for COMT, MAO-A and MAO-B, respectively. COMT-IN-1 exhibits chelation with a variety of metal ions. COMT-IN-1 exhibits good BBB permeability. COMT-IN-1 improves dopamine levels and ameliorates MPTP -induced Parkinson's disease (PD) symptoms in mice[1].

CAS Number

2987884-27-3

UNSPSC

12352211

Target

COMT; Monoamine Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/comt-in-1.html

Smiles

OC1=C([N+]([O-])=O)C=C(/C=C(C(NCC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)=O)\C#N)C=C1O

Molecular Formula

C24H18FN3O6

Molecular Weight

463.41

References & Citations

[1]Manxing Zou, et al. Identification and optimization of nitrophenolic analogues as dopamine metabolic enzyme inhibitors for the treatment of Parkinson's disease. Bioorg Chem. 2024 Jul:148:107488.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAO-A; MAO-B

Related Products

Catalog	Name
HY-168154	COMT-IN-2
HY-P72149-01	COMT, Human (His)
HY-P74230	COMT, Human (sf9, His)
HY-P82269-01	COMT Antibody (YA2014, Rabbit)
HY-151390	HMAO-B/MB-COMT-IN-2
HY-RS03018	Comt Rat Pre-designed siRNA Set A
HY-RS03017	Comt Mouse Pre-designed siRNA Set A
HY-RS03016	COMT Human Pre-designed siRNA Set A
HY-N6838-01	1,1,1,1-Kestohexaose
HY-157129	AMPK-α1β1γ1 activator 1

Alternative Products

Catalog	Name
T89119-01	COMT-IN-1
enz-400	COMT
P38614	PExpress-1-Comt (rat)
PVT52872	pExpress-1-Comt Plasmid
30R-1264	COMT protein
T200677-01	COMT-IN-2
70R-16509	COMT antibody
DF3905-BP	COMT Peptide
MBS8002108-01	COMT Inhibitor

COMT-IN-1

Related Products

Alternative Products

Popular Products