COMT-IN-2

CAT: 804-HY-168154Size: 1 EachDry Ice: NoHazardous: No

1 EachSelected

PRICE

AVAILABILITY

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

1 / 1

Description

COMT-IN-2 (compund 9) is the potent COMT inhibitor, showing selective inhibition of brain (IC50=24 nM) and liver (IC50=81 nM) MB-COMT compared to the liver S-COMT (IC50=620 nM) isoform[1].

UNSPSC

12352005

Target

COMT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/comt-in-2.html

Smiles

O=C1C=CN(C=C1O)C2=CC(C)=C(C=C2)C

Molecular Formula

C13H13NO2

Molecular Weight

215.25

References & Citations

[1]Benfeito S, et al. Discovery of a Potent, Selective, and Blood-Brain Barrier Permeable Non-nitrocatechol Inhibitor of Catechol-O-methyltransferase. J Med Chem. 2024 Oct 24;67 (20) :18384-18399.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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