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COMT-IN-1

CAT: 0931-T89119-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T89119-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2987884-27-3
Bioactivity
COMT-IN-1 (compound C12) is a nitrophenol analog and an orally active catechol-O-methyltransferase (COMT) inhibitor. It exhibits IC50 values of 0.37 ?M for COMT, 95.58 ?M for MAO-A, and 58.82 ?M for MAO-B, demonstrating its inhibitory activity on these enzymes. Additionally, COMT-IN-1 displays chelation properties with various metal ions and has good blood-brain barrier permeability. This compound enhances dopamine levels in mice and ameliorates symptoms of MPTP-induced Parkinsons disease (PD) .
Smiles
FC1=CC=CC(COC(C=C2)=CC=C2CNC(/C(C#N)=C/C3=CC([N+]([O-])=O)=C(C(O)=C3)O)=O)=C1
Molecular Formula
C24H18FN3O6
Molecular Weight
463.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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