(S) -Deoxy-thalidomide

CAT: 0804-HY-168055Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-168055Size:1 Each
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Description
(S) -Deoxy-thalidomide is an E3 ubiquitin ligase ligand. (S) -Deoxy-thalidomide can be linked to the target protein ligand through a linker to form PROTAC K-Ras Degrader-3 (HY-168054) . PROTAC K-Ras Degrader-3 can target KRAS mutant proteins for degradation[1].
CAS Number
[107657-57-8]
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-deoxy-thalidomide.html
Smiles
O=C(CC1)NC([C@H]1N2C(C3=CC=CC=C3C2)=O)=O
Molecular Formula
C13H12N2O3
Molecular Weight
244.25
References & Citations
[1]Robert Luo, et al. Glutarimide-containing pan-kras-mutant degrader compounds and uses thereof. WO2024118966A1. 2023-11-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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