(S) -Deoxy-thalidomide

• Description:

  (S) -Deoxy-thalidomide is an E3 ubiquitin ligase ligand. (S) -Deoxy-thalidomide can be linked to the target protein ligand through a linker to form PROTAC K-Ras Degrader-3 (HY-168054) . PROTAC K-Ras Degrader-3 can target KRAS mutant proteins for degradation[1].

• UNSPSC:

  12352005

• Target:

  Ligands for E3 Ligase

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/s-deoxy-thalidomide.html

• Smiles:

  O=C(CC1)NC([C@H]1N2C(C3=CC=CC=C3C2)=O)=O

• Molecular Formula:

  C13H12N2O3

• Molecular Weight:

  244.25

• References & Citations:

  [1]Robert Luo, et al. Glutarimide-containing pan-kras-mutant degrader compounds and uses thereof. WO2024118966A1. 2023-11-30.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cereblon

• CAS Number:

  [107657-57-8]