(S) -Deoxy-thalidomide

• Description :

  (S) -Deoxy-thalidomide is an E3 ubiquitin ligase ligand. (S) -Deoxy-thalidomide can be linked to the target protein ligand through a linker to form PROTAC K-Ras Degrader-3 (HY-168054) . PROTAC K-Ras Degrader-3 can target KRAS mutant proteins for degradation[1].

• CAS Number :

  [107657-57-8]

• UNSPSC :

  12352005

• Target :

  Ligands for E3 Ligase

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/s-deoxy-thalidomide.html

• Smiles :

  O=C(CC1)NC([C@H]1N2C(C3=CC=CC=C3C2)=O)=O

• Molecular Formula :

  C13H12N2O3

• Molecular Weight :

  244.25

• References & Citations :

  [1]Robert Luo, et al. Glutarimide-containing pan-kras-mutant degrader compounds and uses thereof. WO2024118966A1. 2023-11-30.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon