Deoxy-thalidomide-C4-NH2

• Description :

  Deoxy-thalidomide-C4-NH2 is a ligand-linker conjugate for the E3 ligase Cereblon (CRBN) . Deoxy-thalidomide-C4-NH2 can be used in the synthesis of PROTAC BRD4 Degrader (HY-176449) [1].

• CAS Number :

  [2940934-97-2]

• UNSPSC :

  12352005

• Target :

  E3 Ligase Ligand-Linker Conjugates

• Related Pathways :

  PROTAC

• Field of Research :

  Cancer

• Smiles :

  O=C1NC(C(CC1)N2C(C3=CC=C(CCCCN)C=C3C2)=O)=O

• Molecular Formula :

  C17H21N3O3

• Molecular Weight :

  315.37

• References & Citations :

  [1]Lovato K, et al. Reductive C (sp2) -C (sp3) Coupling Protocol to Enable Linker Exploration of Cereblon E3-Ligase BRD4 Proteolysis-Targeting Chimeras. J Med Chem. 2025 May 22;68 (10) :10061-10074.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported