ABM-14

• Description :

  ABM-14 is a ligand for targeting androgen receptor (AR) for PROTAC. ABM-14 binds to a ligand for VHL via linker to form ARCC-4 (HY-130492) to degrade AR[1].

• UNSPSC :

  12352005

• Target :

  Ligands for Target Protein for PROTAC

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/abm-14.html

• Purity :

  98.17

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  N#CC1=CC=C(N(C(N(C2=CC=C(C3=CC=C(O)C=C3)C=C2)C4(C)C)=S)C4=O)C=C1C(F)(F)F

• Molecular Formula :

  C25H18F3N3O2S

• Molecular Weight :

  481.49

• References & Citations :

  [1]Meizhong Jin, et al. Compounds and methods for the targeted degradation of the androgen receptor. WO2016118666A1.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1973408-76-2]