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SIN 14

CAT: 0804-HY-173518Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173518Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SIN 14, a derivative of Sinomenine , is an orally active HO-1 activator (KD = 17.2 μM). SIN 14 binds to the catalytic core domain of HO-1 and induces HO-1 activation in catalysis. SIN 14 significantly increases HO-1 stability. SIN 14 has anti-inflammatory effects and inhibits M1 macrophage polarization while promoting M2 polarization in LPS (Lipopolysaccharides) (HY-D1056) -induced RAW264.7 cells. SIN 14 inhibits inflammatory mediator production (eg: NO, IL-6, IL-1β and CCL2, inhibits production of ROS and down-regulates the expression of COX-2 and iNOS. SIN 14 can inhibit RA-related inflammatory edema in collagen-induced arthritis (ClA) mice[1].
UNSPSC
12352005
Target
COX; Heme Oxygenase (HO) ; Interleukin Related; NO Synthase; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
COC1=CC=C2C[C@H](N3C)C4[C@@]5(CC3)C(C(O)OC1=C52)=C(Cl)C(OC)=C4
Molecular Formula
C20H22ClNO4
Molecular Weight
375.85
References & Citations
[1]Zheng YZ, et al. Discovery of sinomenine derivatives inhibiting macrophage polarization against rheumatoid arthritis through selectively targeting heme oxygenase-1. Eur J Med Chem. 2025 Aug 5;292:117596.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2; HO-1; IL-1; IL-6; iNOS

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