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8-Azanebularine

CAT: 0804-HY-145442-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145442-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
8-Azanebularine, a compound with hydrogen in place of the C6 amino group, inhibits the ADAR2 reaction at high concentrations (IC50=15 mM) . 8-Azanebularine is incorporated into an RNA structure recognized by human ADAR2 results in high-affinity binding (KD=2 nM) . 8-Azanebularine can be used for the research of ADAR-catalyzed RNA-editing reaction[1].
CAS Number
38874-46-3
UNSPSC
12352005
Target
Adenosine Deaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/8-azanebularine.html
Purity
99.33
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC=C3N=N2
Molecular Formula
C9H11N5O4
Molecular Weight
253.21
References & Citations
[1]Haudenschild BL, et al. A transition state analogue for an RNA-editing reaction. J Am Chem Soc. 2004;126 (36) :11213-11219.|[2]Mendoza HG, et al. Selective Inhibition of ADAR1 Using 8-Azanebularine-Modified RNA Duplexes. Biochemistry. 2023 Apr 18;62 (8) :1376-1387.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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