SAMβA

• Description :

  SAMβA is conjugated to the cell permeable peptide TAT47-57. SAMβA, a rationally designed selective antagonist of Mfn1-βIIPKC association. SAMβA is a selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats[1].

• UNSPSC :

  12352209

• Target :

  PKC

• Type :

  Peptides

• Related Pathways :

  Epigenetics; TGF-beta/Smad

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/samβa.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O

• Molecular Formula :

  C50H73N17O16

• Molecular Weight :

  1168.22

• References & Citations :

  [1]Julio C B Ferreira A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat Commun. 2019 Jan 18;10 (1) :329.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [2429946-75-6]