EW-7195

• Description:

  EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC50 of 4.83 nM. EW-7195 has >300-fold selectivity for ALK5 over p38α. EW-7195 efficiently inhibits TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT) and breast tumour metastasis to the lung[1].

• UNSPSC:

  12352005

• Target:

  P38 MAPK; TGF-β Receptor

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway; TGF-beta/Smad

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ew-7195.html

• Purity:

  98.84

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  N#CC1=CC=CC(NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2)=C1

• Molecular Formula:

  C23H18N8

• Molecular Weight:

  406.44

• References & Citations:

  [1]Park CY, et al. EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung. Eur J Cancer. 2011;47 (17) :2642-2653.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  ALK5; p38α

• CAS Number:

  [1352609-28-9]