OGT-719

• Description:

  OGT-719 is a potent, orally active nucleoside analogue that targets the asialoglycoprotein receptor (ASGP-R) . OGT-719 inhibits growth of metastatic colorectal tumors in the liver of nude mice. OGT-719 can be used for primary hepatocellular carcinoma and colorectal liver metastases research[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Asialoglycoprotein Receptor (ASGPR) ; Nucleoside Antimetabolite/Analog

• Related Pathways:

  Cell Cycle/DNA Damage; Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  O=C1NC (C (F) =CN1[C@H]2[C@@H] ([C@H] ([C@H] ([C@@H] (CO) O2) O) O) O) =O

• Molecular Formula:

  C10H13FN2O7

• Molecular Weight:

  292.22

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Rohlff C, et al. A novel, orally administered nucleoside analogue, OGT 719, inhibits the liver invasive growth of a human colorectal tumor, C170HM2. Cancer Res. 1999 Mar 15;59 (6) :1268-72.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound2

• Clinical Information:

  No Development Reported

• CAS Number:

  185843-61-2