PF-719

CAT: 0804-HY-113788-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-113788-01Size:5 mg
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AVAILABILITY: InStock
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Description
PF-719 is a selective inhibitor of Pyk2 (IC50: 17 nM) . PF-719 inhibits FAK activity (IC50: 469 nM) . PF-719 inhibits the kinase activities of Hck, Fyn, Lck, and Lyn in A20 B-lymphoma cells, with an IC50 of 6.7 μM for Lyn[1].
CAS Number
[1404454-02-9]
UNSPSC
12352005
Target
FAK; Pyk2
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.52
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1CC1)C2=CC=C(NC3=NC=C(C(F)(F)F)C(N[C@H]4[C@H](N(C)C)CCC4)=N3)C=C2
Molecular Formula
C22H27F3N6O
Molecular Weight
448.48
References & Citations
[1]Tse KW, et al. Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells. Cell Immunol. 2012 Jan-Feb;275 (1-2) :47-54.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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