PF-719

• Description:

  PF-719 is a selective inhibitor of Pyk2 (IC50: 17 nM) . PF-719 inhibits FAK activity (IC50: 469 nM) . PF-719 inhibits the kinase activities of Hck, Fyn, Lck, and Lyn in A20 B-lymphoma cells, with an IC50 of 6.7 μM for Lyn[1].

• UNSPSC:

  12352005

• Target:

  FAK; Pyk2

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Purity:

  99.52

• Solubility:

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(NC1CC1)C2=CC=C(NC3=NC=C(C(F)(F)F)C(N[C@H]4[C@H](N(C)C)CCC4)=N3)C=C2

• Molecular Formula:

  C22H27F3N6O

• Molecular Weight:

  448.48

• References & Citations:

  [1]Tse KW, et al. Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells. Cell Immunol. 2012 Jan-Feb;275 (1-2) :47-54.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [1404454-02-9]