EPZ-719

• Description:

  EPZ-719 is a selective, orally effective SETD2 inhibitor with an IC50 value of 0.005 μM. EPZ-719 has anticancer activity[1].

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/epz-719.html

• Purity:

  99.00

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CC1=C2C(C=C(C(N[C@@H]3CCC[C@H](N4C[C@@H](N(S(=O)(C)=O)C)CC4)C3)=O)N2)=C(F)C=C1

• Molecular Formula:

  C22H31FN4O3S

• Molecular Weight:

  450.57

• References & Citations:

  [1]Lampe JW, et al. Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies. ACS Med Chem Lett. 2021 Aug 24;12 (10) :1539-1545.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  SETD2/KMT3A

• CAS Number:

  [2697176-16-0]