Products for Research Use Only
RegisterLogin

Fenobam

CAT: 0804-HY-101478-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-101478-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Fenobam is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam has anxiolytic activity, inhibits self-administration behavior in mice, and induces apoptosis in cancer cells. Fenobam can be used for research on neurological diseases, cancer and drug addiction[1][2][3].
CAS Number
57653-26-6
UNSPSC
12352005
Hazard Statement
H300, H315, H319, H335
Target
Apoptosis; mGluR
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fenobam.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC(CN1C)=O)NC2=CC=CC(Cl)=C2
Molecular Formula
C11H11ClN4O2
Molecular Weight
266.69
Precautions
H300, H315, H319, H335
References & Citations
[1]Porter RH, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005 Nov;315 (2) :711-21.|[2]Keck TM, et al. Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans. Psychopharmacology (Berl) . 2013;229 (2) :253-265.|[3]Liao S, et al. Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole. PLoS One. 2017 Feb 23;12 (2) :e0171256.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MGluR5

Alternative Products

CatalogName
B7035-50Fenobam
NCA54028-01Fenobam (hydrate)
MBS5811514Fenobam hydrate
A20372-200Fenobam 200mg
A20372-25Fenobam 25mg
A20372-10Fenobam 10mg
A20372-100Fenobam 100mg
A20372-50Fenobam 50mg
A20372-5Fenobam 5mg
A20372-1Fenobam 1mg

Popular Products