CPS2

• Description :

  CPS2 is a first-in-class, highly potent, selective and irreversible PROTAC CDK2 degrader (IC50= 24 nM) . CPS2 can be used for the research of acute myeloid leukemia[1].

• UNSPSC :

  12352005

• Target :

  CDK; PROTACs

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; PROTAC

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cps2.html

• Concentration :

  10mM

• Purity :

  99.33

• Solubility :

  DMSO : 32.5 mg/mL (ultrasonic)

• Smiles :

  O=C(N1)CCC(N2C(C3=CC=CC(NCCOCCOCCN4N=NC(COCCNS(C5=CC=C(C=C5)NC6=NN(C(N)=N6)C(C7=C(C=CS7)C)=O)(=O)=O)=C4)=C3C2=O)=O)C1=O

• Molecular Formula :

  C38H42N12O10S2

• Molecular Weight :

  890.94

• References & Citations :

  [1]Wang L, et al. Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy. Nat Chem Biol. 2021;17 (5) :567-575

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  CDK2

• CAS Number :

  [2756741-90-7]