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P53-MDM2-IN-6

CAT: 0804-HY-162927Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162927Size:1 Each
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Description
P53-MDM2-IN-6 (Compound 10a), a LSM-83177 hydrazone analog, is a potent p53-MDM2 inhibitor with an IC50 value of 11.08 µg/mL. p53-MDM2-IN-6 arrests the cell cycle in the S phase and induces early and late Apoptosis with antiproliferative activity against HT29 cell lines with an IC50 value of 10.44 µg/mL. p53-MDM2-IN-6 inhibits p53-MDM2 interaction with increment in p-53 level and decrease the expression of GST enzymes. p53-MDM2-IN-6 is promising for research of colorectal cancer[1].
CAS Number
1054506-59-0
UNSPSC
12352211
Target
Apoptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p53-mdm2-in-6.html
Smiles
O=C(CNC1=CC=CC=C1)N/N=C/C2=CC=C(OCC(O)=O)C=C2
Molecular Formula
C17H17N3O4
Molecular Weight
327.33
References & Citations
[1]Elgohary MK, et al. Development of new LSM-83177 analogues as anti-tumor agents against colorectal cancer targeting p53-MDM2 interaction. Bioorg Chem. 2024 Aug 28;153:107766.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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