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Spexin

CAT: 0804-HY-P1723-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P1723-01Size:1 mg
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Description
Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents) . Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142) -induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy[1][2][3].
CAS Number
[1370290-58-6]
Product Name Alternative
Neuropeptide Q
UNSPSC
12352209
Target
Apoptosis; Autophagy; Ferroptosis; Neuropeptide Y Receptor
Type
Peptides
Related Pathways
Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/spexin.html
Purity
99.94
Solubility
H2O : 25 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(NCC(N[C@@H](C)C(N[C@H](C(N)=O)CCC(N)=O)=O)=O)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)NC([C@@H](NC([C@@H](N)CC(N)=O)=O)CC3=CNC4=CC=CC=C34)=O
Molecular Formula
C74H114N20O19S
Molecular Weight
1619.88
References & Citations
[1]Porzionato A, et al. Spexin expression in normal rat tissues. J Histochem Cytochem. 2010;58 (9) :825-837.|[2]Ou W, et al. Spexin inhibits excessive autophagy-induced ferroptosis to alleviate doxorubicin-induced cardiotoxicity by upregulating Beclin 1. Br J Pharmacol. 2024 Nov;181 (21) :4195-4213.|[3]Walewski JL, et al. Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. Obesity (Silver Spring) . 2014 Jul;22 (7) :1643-52.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported

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