Frovatriptan-d3 (hydrochloride)

Frovatriptan-d3 (hydrochloride)

• UNSPSC Description: Frovatriptan-d3 (hydrochloride) is the deuterium labeled Frovatriptan[1]. Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura[2].
• Target Antigen: 5-HT Receptor
• Type: Isotope-Labeled Compounds
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: NC(C1=CC=C2NC(CC[C@H](C3)NC([2H])([2H])[2H])=C3C2=C1)=O.Cl
• Molecular Weight: 282.78
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Stefan Evers, et al. Efficacy of frovatriptan as compared to other triptans in migraine with aura.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported