NLRP3-IN-41

NLRP3-IN-41

• CAS Number: 1209698-02-1
• UNSPSC Description: NLRP3-IN-41 (compd S-9) is an orally active and brain-penetrant NLRP3 inhibitor with anti-inflammatory activities, anti-neuroinflammatory effect and without obvious cytotoxicity. NLRP3-IN-41 inhibits the priming and activation stages of the NLRP3 inflammasome and can be used for inflammasome-related diseases research[1].
• Target Antigen: NOD-like Receptor (NLR)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/nlrp3-in-41.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(N1CCCC2=CC=C(C=C21)NS(=O)(C3=CC=C(C=C3)C4=CC=CC=C4)=O)(C)=O
• Molecular Weight: 442.55
• References & Citations: [1]Yang F, et al. Identification and Validation of PKR as a Direct Target for the Novel Sulfonamide-Substituted Tetrahydroquinoline Nonselective Inhibitor of the NLRP3 Inflammasome. J Med Chem. 2024 Jun 10.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported