NLRP3-IN-55

NLRP3-IN-55

• UNSPSC Description: NLRP3-IN-55 (Compound 19) is a potent NLRP3 inhibitor (IC50 = 0.34 μM). NLRP3-IN-55 directly targets the NLRP3 protein (KD = 0.45 μM), blocking the assembly and activation of the NLRP3 inflammasome, leading to anti-inflammatory effects and inhibition of cellular pyroptosis[1].
• Target Antigen: NOD-like Receptor (NLR); Pyroptosis
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/nlrp3-in-55.html
• Smiles: CCC(NC1=CC=C(C=C1)C2=CC=CC=C2N(C(C3=CC=C(C=C3)F)=O)CC4=CC(Cl)=CC=C4OCCOC)=O
• Molecular Weight: 561.04
• References & Citations: [1]Kang T, et al. Design, synthesis and biological evaluation of novel diphenylamine analogues as NLRP3 inflammasome inhibitors. Bioorg Med Chem. 2024 Nov 1;113:117927.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported