NLRP3-IN-61

NLRP3-IN-61

• CAS Number: 3060585-94-3
• UNSPSC Description: NLRP3-IN-61 (Compound 1) is an inhibitor for NLRP3. NLRP3-IN-61 inhibits pyroptosis in THP-1 cell with an IC50 of 12.6 nM, inhibits IL-β release with an IC50 of 25.3 nM[1].
• Target Antigen: NOD-like Receptor (NLR); Pyroptosis
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/nlrp3-in-61.html
• Smiles: OC1=C(CCC2)C2=CC(C)=C1C3=CC=C(OC([C@@H]4CCC(NC4)=O)=N5)C5=N3
• Molecular Weight: 363.41
• References & Citations: [1]BOUCHE LA, et al., 5-[5-(2-hydroxyphenyl)oxazolo[4,5-b]pyridin-2-yl]piperidin-2-one derivatives as nlpr3 inhibitors for the treatment of inflammatory diseases. WO2024218188
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported