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DUOX1 rabbit pAb

CAT: 0855-ES16881-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES16881-01Size:50 µL
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Background
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
Description
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012],
UniProt
Q9NRD9
Swiss Prot
Q9NRD9
Reactivity
Human; Rat
Immunogen
Synthesized peptide derived from human DUOX1 AA range: 1398-1448
Target
DUOX1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Apical cell membrane ; Multi-pass membrane protein . Localizes to the apical membrane of epithelial cells.
Gene ID (Human)
53905

UniProtKB · Q9NRD9

Dual oxidase 1

DUOX1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NRD9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DUOX1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.-.-.-, 1.11.1.-, 1.6.3.1
Processing
Precursor
Secondary accessions
A6NH28, Q14C94, Q6ZMB3, Q6ZR09, Q9NZC1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumFADFlavoproteinHemeIronMetal-bindingNADP

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Biological process

Hydrogen peroxideThyroid hormones biosynthesis

Molecular function

OxidoreductasePeroxidase

Domain

RepeatSignalTransmembraneTransmembrane helix

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