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RET-IN-27

CAT: 0804-HY-168105Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168105Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RET-IN-27 (compound 20p) is a potent inhibitor of RET, with IC50s of 3.6 nM, 0.1 nM, 2.1 nM, 0.3 nM for RETWT, RETV804L, RETV804M, RETM918T, respectively. RET-IN-27 plays an important role in cancer research[1].
UNSPSC
12352005
Target
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ret-in-27.html
Smiles
N#CC1=CC(CN2C3CN(C4=NC=C(C5=C6C=CC=NC6=CC(C7=CN(C)N=C7)=N5)C=C4)CC2C3)=CC=C1OC
Molecular Formula
C31H28N8O
Molecular Weight
528.61
References & Citations
[1]Junbo Wu, et al. Discovery of 7- (1-methyl-1H-pyrazol-4-yl) -1,6-naphthyridine derivatives as potent inhibitors of rearranged during transfection (RET) and RET solvent-front mutants for overcoming selpercatinib resistance. Eur J Med Chem. 2024 Sep 19:279:116891.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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