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Alpha-Estradiol-d2

CAT: 0804-HY-B0141AS1-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0141AS1-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alpha-Estradiol-d2 is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia[1].
CAS Number
81586-94-9
Product Name Alternative
Alfatradiol-d2; Epiestradiol-d2; Epiestrol-d2
UNSPSC
12352005
Target
5 alpha Reductase; Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Purity
99.0
Solubility
10 mM in DMSO|DMSO : 62.5mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 11.11mg/mL (ultrasonic)
Smiles
C[C@@]12[C@H](O)CC[C@@]1([H])[C@]3([H])CCC4=C(C=C([2H])C(O)=C4[2H])[C@@]3([H])CC2
Molecular Formula
C18H22D2O2
Molecular Weight
274.39
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Santos RS, et al. The effects of 17 alpha-estradiol to inhibit inflammation in vitro. Biol Sex Differ. 2017 Sep 6;8:30.|[3]Schriefers H, et al. Inhibition of testosterone metabolism by 17-alpha-estradiol in rat liver slices. Arzneimittelforschung. 1991 Nov;41 (11) :1186-9.|[4]Zhang HB, et al. 17-Alpha-estradiol ameliorating oxygen-induced retinopathy in a murine model. Jpn J Ophthalmol. 2012 Jul;56 (4) :407-15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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