Alpha-Estradiol-d2

• Description:

  Alpha-Estradiol-d2 is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia[1].

• Product Name Alternative:

  Alfatradiol-d2; Epiestradiol-d2; Epiestrol-d2

• UNSPSC:

  12352005

• Target:

  5 alpha Reductase; Endogenous Metabolite

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease; Cardiovascular Disease

• Purity:

  99.0

• Solubility:

  10 mM in DMSO|DMSO : 62.5mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 11.11mg/mL (ultrasonic)

• Smiles:

  C[C@@]12[C@H](O)CC[C@@]1([H])[C@]3([H])CCC4=C(C=C([2H])C(O)=C4[2H])[C@@]3([H])CC2

• Molecular Formula:

  C18H22D2O2

• Molecular Weight:

  274.39

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Santos RS, et al. The effects of 17 alpha-estradiol to inhibit inflammation in vitro. Biol Sex Differ. 2017 Sep 6;8:30.|[3]Schriefers H, et al. Inhibition of testosterone metabolism by 17-alpha-estradiol in rat liver slices. Arzneimittelforschung. 1991 Nov;41 (11) :1186-9.|[4]Zhang HB, et al. 17-Alpha-estradiol ameliorating oxygen-induced retinopathy in a murine model. Jpn J Ophthalmol. 2012 Jul;56 (4) :407-15.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  81586-94-9