Estriol-d2

CAT: 0804-HY-B0412S-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-B0412S-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Estriol-d2 is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.
CAS Number
[53866-32-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; Estrogen Receptor/ERR; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Purity
98.47
Solubility
DMSO : 250 mg/mL (ultrasonic; warming)
Smiles
OC1=C(C=C2C(CC[C@@]3([C@@]2(CC[C@]4([C@]3(C[C@H]([C@@H]4O)O)[H])C)[H])[H])=C1[2H])[2H]
Molecular Formula
C18H22D2O3
Molecular Weight
290.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Morinaga, A., et al., Effects of sex hormones on Alzheimer's disease-associated beta-amyloid oligomer formation in vitro. Exp Neurol, 2011. 228 (2) : p. 298-302.|[3]Begum, M., et al., Neonatal estrogenic exposure suppresses PTEN-related endometrial carcinogenesis in recombinant mice. Lab Invest, 2006. 86 (3) : p. 286-96.|[4]Hewitt, S.C. and K.S. Korach, Estrogenic activity of bisphenol A and 2,2-bis (p-hydroxyphenyl) -1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles. Environ Health Perspect, 2011. 119 (1) : p. 63-70.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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