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Methacycline

CAT: 0804-HY-W587701-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W587701-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methacycline is a tetracycline antibiotic that inhibits bacterial protein synthesis. Methacycline is a potent inhibitor of epithelial-to-mesenchymal transition (EMT) . Methacycline blocks EMT in vitro and inhibits fibrogenesis in vivo without directly affecting TGF-β1 Smad signaling. Methacycline is an antimicrobial agent with potential for use in pulmonary fibrosis research[1].
CAS Number
914-00-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Assay Protocol
https://www.medchemexpress.com/methacycline.html
Smiles
O[C@]12[C@]([C@H]([C@@]3([H])C(C(C4=C(O)C=CC=C4C3=C)=O)=C2O)O)([H])[C@@H](C(O)=C(C1=O)C(N)=O)N(C)C
Molecular Formula
C22H22N2O8
Molecular Weight
442.42
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Ying Xi, et al. Inhibition of epithelial-to-mesenchymal transition and pulmonary fibrosis by methacycline. Am J Respir Cell Mol Biol. 2014 Jan;50 (1) :51-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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