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Methacholine (chloride) (Standard)

CAT: 0804-HY-A0083R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0083R-01Size:10 mg
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Description
Methacholine (chloride) (Standard) is the analytical standard of Methacholine (chloride) . This product is intended for research and analytical applications. Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR) . Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4].
CAS Number
62-51-1
Product Name Alternative
Acetyl-β-methylcholine chloride (Standard)
UNSPSC
12352211
Target
MAChR; Reference Standards
Type
Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/methacholine-chloride-standard.html
Smiles
CC(OC(C)=O)C[N+](C)(C)C.[Cl-]
Molecular Formula
C8H18ClNO2
Molecular Weight
195.69
References & Citations
[1]Cohen J, et al. Relationship between airway responsiveness to neurokinin A and methacholine in asthma. Pulm Pharmacol Ther. 2005;18 (3) :171-176.|[2]Anderson SD, et al. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res. 2009;10 (1) :4. Published 2009 Jan 23.|[3]Cockcroft DW. Methacholine challenge methods. Chest. 2008;134 (4) :678-680.|[4]Kabara S, et al. Differential effects of thiopental on methacholine- and serotonin-induced bronchoconstriction in dogs. Br J Anaesth. 2003 Sep;91 (3) :379-84.|[5]Folkerts G, et al. Bradykinin causes inhibition of methacholine-induced bronchoconstriction in vivo in mice. Naunyn Schmiedebergs Arch Pharmacol. 2001 Jul;364 (1) :53-8. |[6]Vitorasso RL, et al. Methacholine dose response curve and acceptability criteria of respiratory mechanics modeling. Exp Lung Res. 2020 Feb-Mar;46 (1-2) :23-31.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Methacholine Chloride

Methacholine chloride is a quaternary ammonium salt. It contains a methacholine.

CAS Number62-51-1
PubChem CID6114
IUPAC Name2-acetyloxypropyl(trimethyl)azanium chloride
Molecular FormulaC8H18ClNO2
Molecular Weight195.69
Topological Polar Surface Area26.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count12
Formal Charge0
Complexity138
SMILES
CC(C[N+](C)(C)C)OC(=O)C.[Cl-]
InChI
InChI=1S/C8H18NO2.ClH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1
InChIKey
JHPHVAVFUYTVCL-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of Methacholine Chloride
CAS: 62-51-1
CID: 6114
Formula: C8H18ClNO2
MW: 195.69
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight195.69
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass195.1026065
Monoisotopic Mass195.1026065
Topological Polar Surface Area26.3 Ų
Heavy Atom Count12
Formal Charge0
Complexity138
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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