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Methacholine (chloride)

CAT: 0804-HY-A0083-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0083-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR) . Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4].
CAS Number
62-51-1
Product Name Alternative
Acetyl-β-methylcholine chloride
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Methacholine-chloride.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
CC(OC(C)=O)C[N+](C)(C)C.[Cl-]
Molecular Formula
C8H18ClNO2
Molecular Weight
195.69
Precautions
H302, H315, H319, H335
References & Citations
[1]Cohen J, et al. Relationship between airway responsiveness to neurokinin A and methacholine in asthma. Pulm Pharmacol Ther. 2005;18 (3) :171-176.|[2]Anderson SD, et al. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res. 2009;10 (1) :4. Published 2009 Jan 23.|[3]Cockcroft DW. Methacholine challenge methods. Chest. 2008;134 (4) :678-680.|[4]Kabara S, et al. Differential effects of thiopental on methacholine- and serotonin-induced bronchoconstriction in dogs. Br J Anaesth. 2003 Sep;91 (3) :379-84.|[5]Folkerts G, et al. Bradykinin causes inhibition of methacholine-induced bronchoconstriction in vivo in mice. Naunyn Schmiedebergs Arch Pharmacol. 2001 Jul;364 (1) :53-8. |[6]Vitorasso RL, et al. Methacholine dose response curve and acceptability criteria of respiratory mechanics modeling. Exp Lung Res. 2020 Feb-Mar;46 (1-2) :23-31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAChR3
Citation 01
Aging (Albany NY) . 2021 Sep 13;13 (17) :21729-21742.|Cell Death Dis. 2025 Oct 7;16 (1) :716.|Immunobiology. 2025 Jul 16;230 (4) :153103.|J Ethnopharmacol. 2025 Oct 22:356:120782.|Naunyn Schmiedebergs Arch Pharmacol. 2025 Nov 12.|Mol Immunol. 2023 Oct:162:74-83.

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