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Methacholine (bromide)

CAT: 0804-HY-A0083BSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-A0083BSize:1 Each
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Description
Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR) . Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4].
CAS Number
[333-31-3]
Product Name Alternative
Acetyl-β-methylcholine (bromide)
UNSPSC
12352211
Hazard Statement
H315-H319-H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/methacholine-bromide.html
Solubility
10 mM in DMSO
Smiles
CC(OC(C)=O)C[N+](C)(C)C.[Br-]
Molecular Formula
C8H18BrNO2
Molecular Weight
240.14
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
References & Citations
[1]Cohen J, et al. Relationship between airway responsiveness to neurokinin A and methacholine in asthma. Pulm Pharmacol Ther. 2005;18 (3) :171-176.|[2]Anderson SD, et al. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res. 2009;10 (1) :4. Published 2009 Jan 23.|[3]Cockcroft DW. Methacholine challenge methods. Chest. 2008;134 (4) :678-680.|[4]Kabara S, et al. Differential effects of thiopental on methacholine- and serotonin-induced bronchoconstriction in dogs. Br J Anaesth. 2003 Sep;91 (3) :379-84.|[5]Folkerts G, et al. Bradykinin causes inhibition of methacholine-induced bronchoconstriction in vivo in mice. Naunyn Schmiedebergs Arch Pharmacol. 2001 Jul;364 (1) :53-8. |[6]Vitorasso RL, et al. Methacholine dose response curve and acceptability criteria of respiratory mechanics modeling. Exp Lung Res. 2020 Feb-Mar;46 (1-2) :23-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAChR3

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