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FXR agonist 9

CAT: 0804-HY-168629Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168629Size:1 Each
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Description
FXR agonist 9 (compound 26) is an oral active and selectivity FXR partial agonist with the EC50 of 0.09 µM (75.13 % maximum efficacy). FXR agonist 9 ameliorates pathological features in HFD and CCl4 -induced metabolic dysfunction-associated steatohepatitis mice[1].
CAS Number
2982502-32-7
UNSPSC
12352211
Target
FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fxr-agonist-9.html
Smiles
O=C(NC1=CC=CC=C1C(NC2=CC=CC(C(O)=O)=C2)=O)CCCOC3=CC=C(C(C)(C)C)C=C3
Molecular Formula
C28H30N2O5
Molecular Weight
474.55
References & Citations
[1]Chen C, et al. Design, synthesis and FXR partial agonistic activity of anthranilic acid derivatives bearing aryloxy moiety as therapeutic agents for metabolic dysfunction-associated steatohepatitis. Bioorg Chem. Published online November 3, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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