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FXR agonist 10

CAT: 0804-HY-168331Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168331Size:1 Each
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Description
FXR agonist 10 (Compound 27) is an agonist for FXR with an EC50 of 14.26 μM. FXR agonist 10 upregulates the expression of SHP and BSEP proteins, downregulates the expression of NTCP and CYP7A1 proteins. FXR agonist 10 ameliorates the ANIT-induced cholestasis in mouse model[1].
UNSPSC
12352005
Target
FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/fxr-agonist-10.html
Smiles
C[C@@H]1C[C@]2(O)C(C(C)(C)OO2)=C[C@]34[C@](O4)(C)CC[C@@]31[H]
Molecular Formula
C15H22O4
Molecular Weight
266.33
References & Citations
[1]Yao Z, et al., The discovery of a new potent FXR agonist based on natural product screening. Bioorg Chem. 2024 Feb;143:106979.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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