FXR agonist 15

• Description :

  FXR agonist 15 is a selective, potent and orally active farnesoid X receptor (FXR) agonist with EC50 of 0.76 μM. FXR agonist 15 exhibits no obvious activation on other nuclear receptors including LXRα/β, PXR, PPARα/β/γ, THR-β, with EC50 values all >10 μM. FXR agonist 15 can alleviate steatosis, lobular inflammation, hepatocyte ballooning and liver fibrosis. FXR agonist 15 can be used for the research of nonalcoholic steatohepatitis (NASH) [1].

• CAS Number :

  [2991276-14-1]

• UNSPSC :

  12352100

• Target :

  FXR

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Inflammation/Immunology

• Smiles :

  FC1=CC(C2=CC=C(N(S(=O)(C3=C(Cl)C=CC=C3Cl)=O)CC(C)C)C=C2)=CC=C1OCC(O)=O

• Molecular Formula :

  C24H22Cl2FNO5S

• Molecular Weight :

  526.40

• References & Citations :

  [1]Wang W, et al. Design, synthesis, and biological studies of novel sulfonamide derivatives as farnesoid X receptor agonists. Eur J Med Chem. 2023;258:115614.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported