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FXR agonist 7

CAT: 0804-HY-163466Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163466Size:1 Each
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Description
FXR agonist 7 (compound 33) is a potent agonist of FXR, with EC50 of 0.1 nM. FXR agonist 7 shows high intestinal distribution, good anti-inflammatory activity[1].
UNSPSC
12352005
Target
FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fxr-agonist-7.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN(C2=C1C=CC(N3CCC4(CC3)CC(C4)COCC5=C(ON=C5C6=CC=CC=C6OC(F)(F)F)C7CC7)=C2)CC)O
Molecular Formula
C34H36F3N3O5
Molecular Weight
623.66
References & Citations
[1]Yuan Li, et al. Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2024 Apr 11;67 (7) :5642-5661.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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