Anticancer agent 233

CAT: 0804-HY-163770Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-163770Size:1 Each
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Description
Anticancer agent 233 (compound 5g) is a 3,5-bis (arylmethylene) -4-piperidinone derivative with anticancer activity, with GI50 of 0.25 and 0.23 μM for cervical cancer (HeLa) and colon cancer (HCT116) cell lines, respectively. The chlorine atom on the aromatic ring of Anticancer agent 233 interacts well with the catalytic site of 20S proteasome, inhibiting the activity of 20S proteasome to exert its anticancer effect[1].
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-233.html
Smiles
O=C1/C(CN(C(CC2=CN=C(N)S2)=O)C/C1=C\C3=CC=C(Cl)C=C3Cl)=C\C4=CC=C(Cl)C=C4Cl
Molecular Formula
C24H17Cl4N3O2S
Molecular Weight
553.29
References & Citations
[1]Loori S, et al. Synthesis of novel aryl-substituted 2-aminopyridine derivatives by the cascade reaction of 1, 1-enediamines with vinamidinium salts to develop novel anti-Alzheimer agents[J]. Scientific Reports, 2024, 14 (1) : 13780.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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