Anticancer agent 233

• Description:

  Anticancer agent 233 (compound 5g) is a 3,5-bis (arylmethylene) -4-piperidinone derivative with anticancer activity, with GI50 of 0.25 and 0.23 μM for cervical cancer (HeLa) and colon cancer (HCT116) cell lines, respectively. The chlorine atom on the aromatic ring of Anticancer agent 233 interacts well with the catalytic site of 20S proteasome, inhibiting the activity of 20S proteasome to exert its anticancer effect[1].

• UNSPSC:

  12352005

• Target:

  Proteasome

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-233.html

• Smiles:

  O=C1/C(CN(C(CC2=CN=C(N)S2)=O)C/C1=C\C3=CC=C(Cl)C=C3Cl)=C\C4=CC=C(Cl)C=C4Cl

• Molecular Formula:

  C24H17Cl4N3O2S

• Molecular Weight:

  553.29

• References & Citations:

  [1]Loori S, et al. Synthesis of novel aryl-substituted 2-aminopyridine derivatives by the cascade reaction of 1, 1-enediamines with vinamidinium salts to develop novel anti-Alzheimer agents[J]. Scientific Reports, 2024, 14 (1) : 13780.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [9007-83-4]