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KP-2067

CAT: 0804-HY-179475Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179475Size:1 Each
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Description
KP-2067 is a form of the CaSR agonist peptide. KP-2067 can result in dose-dependent activation of CaSR in HEK293T overexpressing hCaSR cell line, with an EC50 of 18.4 μM. KP-2067 significantly reduces plasma parathyroid hormone in rat model[1].
CAS Number
[1262781-19-0]
UNSPSC
12352209
Target
CaSR
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Smiles
N=C(N)NCCC[C@H](C(N)=O)NC([C@@H](C)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](C)NC([C@@H](CS)NC(C)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C35H68N20O8S
Molecular Weight
929.11
References & Citations
[1]Alexander, S. T., et al., (2015) . Critical Cysteine Residues in Both the Calcium-Sensing Receptor and the Allosteric Activator AMG 416 Underlie the Mechanism of Action. Molecular pharmacology, 88 (5), 853-865.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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