KP-2067

• Description:

  KP-2067 is a form of the CaSR agonist peptide. KP-2067 can result in dose-dependent activation of CaSR in HEK293T overexpressing hCaSR cell line, with an EC50 of 18.4 μM. KP-2067 significantly reduces plasma parathyroid hormone in rat model[1].

• UNSPSC:

  12352209

• Target:

  CaSR

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology

• Smiles:

  N=C (N) NCCC[C@H] (C (N) =O) NC ([C@@H] (C) NC ([C@@H] (CCCNC (N) =N) NC ([C@@H] (CCCNC (N) =N) NC ([C@@H] (CCCNC (N) =N) NC ([C@@H] (C) NC ([C@@H] (CS) NC (C) =O) =O) =O) =O) =O) =O) =O

• Molecular Formula:

  C35H68N20O8S

• Molecular Weight:

  929.11

• References & Citations:

  [1]Alexander, S. T., et al., (2015) . Critical Cysteine Residues in Both the Calcium-Sensing Receptor and the Allosteric Activator AMG 416 Underlie the Mechanism of Action. Molecular pharmacology, 88 (5), 853-865.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1262781-19-0