ML-180

ML-180

• Product Name Alternative: SPDP Crosslinker; Py-ds-Prp-OSu
• CAS Number: 863588-32-3
• UNSPSC Description: ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM). ML-180 has the potential for LRH-1-dependent cancers[1][2].
• Target Antigen: Orphan Receptor
• Type: Reference compound
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ml-180.html
• Purity: 99.06
• Solubility: DMSO : 11.9 mg/mL (ultrasonic)
• Smiles: O=C1N(C2CCCCC2)C(C=C(N3CCN(C4=CC=CC(Cl)=C4)CC3)N1)=O
• Molecular Weight: 388.89
• References & Citations: [1]Busby S, et al. Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2).|[2]Corzo CA, et al. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1. Mol Pharmacol. 2015 Feb;87(2):296-304.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported