S-23

CAT: 0804-HY-112257-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112257-01Size:5 mg
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Description
S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR) -mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats[1][2].
CAS Number
[1010396-29-8]
UNSPSC
12352005
Hazard Statement
H302, H413
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/s-23.html
Purity
99.63
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[C@@](C)(O)COC2=CC=C(Cl)C(F)=C2
Molecular Formula
C18H13ClF4N2O3
Molecular Weight
416.75
Precautions
H302, H413
References & Citations
[1]Jones A, et al. Preclinical characterization of a (S) -N- (4-cyano-3-trifluoromethyl-phenyl) -3- (3-fluoro, 4-chlorophenoxy) -2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception. Endocrinology. 2009;150 (1) :385-395.|[2]Thevis M, et al. Characterization of in vitro generated metabolites of the selective androgen receptor modulators S-22 and S-23 and in vivo comparison to post-administration canine urine specimens. Drug Test Anal. 2010;2 (11-12) :589-598.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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