PROTAC CDK4/6 degrader 1

PROTAC CDK4/6 degrader 1

• CAS Number: 3025082-14-5
• UNSPSC Description: PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader for CDK4 and CDK6 with DC50 of 10.5 and 2.5 nM. PROTAC CDK4/6 degrader 1 inhibits the proliferation of cell Jurkat (IC50 is 0.18 μM), arrests the cell cycle at G1 phase and induces apoptosis. (Pink: ligand for target protein YY173 (HY-163787); Black: linker (HY-163788); Blue: ligand for E3 ligase (HY-10984))[1]
• Target Antigen: Apoptosis; CDK; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;PROTAC
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-cdk4-6-degrader-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)CCCCC(NCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)=O)=NC=C2N=C1)C8CCCC8
• Molecular Weight: 789.88
• References & Citations: [1]He H, et al., Development of Degraders of Cyclin-Dependent Kinases 4 and 6 Based on Rational Drug Design. J Med Chem. 2024 Jul 11;67(13):11354-11364.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported