PPQ-102
CAT:
804-HY-14179-01
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PPQ-102
- CAS Number: 931706-15-9
- UNSPSC Description: PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease[1].
- Target Antigen: CFTR
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel
- Field of Research: Others
- Assay Protocol: https://www.medchemexpress.com/PPQ-102.html
- Solubility: DMSO : 50 mg/mL (ultrasonic)
- Smiles: CN1C(C2=C(C3=CC=CC=C3)N4C5=CC=CC=C5NC(C6=CC=C(C)O6)C4=C2N(C)C1=O)=O
- Molecular Weight: 438.48
- References & Citations: [1]Tradtrantip L, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52(20):6447-55.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported