PPQ-102

PPQ-102

• CAS Number: 931706-15-9
• UNSPSC Description: PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease[1].
• Target Antigen: CFTR
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/PPQ-102.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: CN1C(C2=C(C3=CC=CC=C3)N4C5=CC=CC=C5NC(C6=CC=C(C)O6)C4=C2N(C)C1=O)=O
• Molecular Weight: 438.48
• References & Citations: [1]Tradtrantip L, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52(20):6447-55.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported